PLAC3 Antibody
Product Specifications
Background
PLAC3 Antibody: PLAC3 (placenta-specific protein 3), also known as PAPP-A2, is a metalloproteinase that cleaves the insulin-like growth factor-binding protein (IGFBP) -5 in a IGF-independent fashion. It has been suggested that the cleavage of IGFBP-5 and to a lesser extent IGFBP-3 produced in the maternal decidua promotes feto-placental growth. Recent studies have shown elevated levels of PLAC3 in hypertensive disorders of pregnancy including preeclampsia and HELLP (hemolysis, elevated liver enzymes, and low platelets) syndrome.
NCBI Gene ID
60676
Swiss Prot
Q9BXP8
Accession Number
NP_064714
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
PLAC3 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Buffer
PLAC3 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
PLAC3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=6019
Fragment
IgG
Symbol
PAPPA2
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Pappalysin 2
NCBI Organism
Homo sapiens
Background Reference 01
Overgaard MT, Boldt HB, Laursen LS, et al. Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase. J. Biol. Chem.2001; 276:1849-53.
Background Reference 02
Wang J, Qiu Q, Haider M, et al. Expression of pregnancy-associated plasma protein A2 during pregnancy in human and mouse. J. Endocrin.2009; 202:337-45.
Background Reference 03
Nishizawa H, Pryor-Koishi K, Suzuki M, et al. Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients. Mol. Hum. Reprod.2008; 14:595-602.
Background Reference 04
Buimer M, Keijser R, Jebbink JM, et al. Seven placental transcripts characterize HELLP syndrome. Placenta2008; 29:444-53.
Other Product Names
PLAC3 Antibody: PAPPE, PLAC3, PAPP-E, PAPP-A2, Pappalysin-2, Pregnancy-associated plasma protein A2
Tested Applications
ELISA, WB, ICC, IF
Protein ID
116174738
Physical Properties
Liquid
Available Sizes
Curated Selection
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