KPNA7 Antibody
Product Specifications
Background
KPNA7 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA7 is most closely related to KPNA2, but unlike KPNA2, KPNA7 primarily localizes to the nucleus. It has been suggested that KPNA7 may play a role in the transport of essential nuclear proteins required for early embryogenesis.
NCBI Gene ID
402569
Swiss Prot
A9QM74
Accession Number
NP_001139187
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
KPNA7 Antibody is affinity chromatography purified via peptide column.
Concentration
1 mg/mL
Buffer
KPNA7 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
KPNA7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
KPNA7 antibody is human specific. KPNA7 antibody is predicted to not cross-react with other Importin alpha family members.
Symbol
KPNA7
NCBI Official Name
Karyopherin alpha 7 (importin alpha 8)
NCBI Organism
Homo sapiens
Background Reference 01
Moroianu J. Molecular mechanisms of nuclear protein transport. Crit. Rev. Eukaryot. Gene. Expr. 1997; 7:61-72.
Background Reference 02
Gilchrist D and Rexach M. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J. Biol. Chem. 2003; 278: 51937-49.
Background Reference 03
Tejomurtula J, Lee KB, Tripurani SK, et al. Role of importin alpha8, a new member of the importin alpha family of nuclear transport proteins, in early embryonic development in cattle. Biol. Reprod. 2009; 81:333-42.
Background Reference 04
Kelley JB, Talley AM, Spencer A, et al. Karyopherin a7 (KPNA7), a divergent member of the importin a family of nuclear import receptors. BMC Cell Biol. 2010; 11:63.
Other Product Names
KPNA7 Antibody: Importin subunit alpha-8, Karyopherin subunit alpha-7
Tested Applications
ELISA, WB, IHC-P
Protein ID
224589129
Physical Properties
Liquid
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
