KPNA7 Antibody

Product Specifications

Background

KPNA7 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA7 is most closely related to KPNA2, but unlike KPNA2, KPNA7 primarily localizes to the nucleus. It has been suggested that KPNA7 may play a role in the transport of essential nuclear proteins required for early embryogenesis.

NCBI Gene ID

402569

Swiss Prot

A9QM74

Accession Number

NP_001139187

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

KPNA7 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Buffer

KPNA7 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

KPNA7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

KPNA7 antibody is human specific. KPNA7 antibody is predicted to not cross-react with other Importin alpha family members.

Symbol

KPNA7

NCBI Official Name

Karyopherin alpha 7 (importin alpha 8)

NCBI Organism

Homo sapiens

Background Reference 01

Moroianu J. Molecular mechanisms of nuclear protein transport. Crit. Rev. Eukaryot. Gene. Expr. 1997; 7:61-72.

Background Reference 02

Gilchrist D and Rexach M. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J. Biol. Chem. 2003; 278: 51937-49.

Background Reference 03

Tejomurtula J, Lee KB, Tripurani SK, et al. Role of importin alpha8, a new member of the importin alpha family of nuclear transport proteins, in early embryonic development in cattle. Biol. Reprod. 2009; 81:333-42.

Background Reference 04

Kelley JB, Talley AM, Spencer A, et al. Karyopherin a7 (KPNA7), a divergent member of the importin a family of nuclear import receptors. BMC Cell Biol. 2010; 11:63.