BANP Antibody

BANP Antibody: BANP was initially identified as a binding protein to BTG3 in a yeast two-hybrid screen. BANP acts as a tumor suppressor by stabilizing p53 expression and leading to cell cycle arrest. p53 in turn binds to upstream elements of the BANP promoter, thereby forming a feedback loop. BANP is down-regulated in advanced stages of human breast cancer, and its overexpression in breast cancer cell lines inhibits their ability to metastasize by modulating TGF-beta signaling. Furthermore, BANP can modulate NF-κ B transactivation and can inhibit tumorigenesis by regulating NF-κ B target genes. Recent experiments have shown that BANP can also repress HIV-1 LTR mediated transcription by tethering the LTR matrix attachment region to nuclear matrix.

BANP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Kaul R, Mukherjee S, Ahmed F, et al. Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice. Int. J. Cancer2003; 103:606-15.

Singh K, Mogare D, Giridharagopalan RO, et al. P%3 target gene SMAR1 is dysregulated in breast cancer: its role in cancer cell migration and invasion. PLoS One2007; 2:e660.

Signh K, Sinha S, Malonia SK, et al. Tumor suppressor SMAR1 repsses IkBa expression and inhibits p65 transactivation through matrix attachment regions. J. Biol. Chem.2009; 284:1267-78.