What is the catalog number for NALP5 Antibody?

The catalog number for NALP5 Antibody is 5959.

What sizes are available for NALP5 Antibody?

NALP5 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does NALP5 Antibody come in?

NALP5 Antibody is available in 2 different pack sizes.

Is NALP5 Antibody in stock?

NALP5 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

NALP5 Antibody

Product Specifications

Background

NALP5 Antibody: NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP5, also known as MATER, is a maternal gene required for early embryonic development in mice. Increased NALP5 expression was observed in two neuronal injury models, and transient expression of recombinant NALP5 in neurons induced caspase-3 activation and apoptosis, suggesting that NALP5 also plays a role in caspase activation and apoptosis in injured neurons, and may thus represent a novel target for therapeutic treatment in neurodegenerative disorders.

NCBI Gene ID

126206

Swiss Prot

P59047

Accession Number

NP_703148

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

NALP5 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1403 - Mouse Brain Tissue Lysate

Concentration

1 mg/mL

Buffer

NALP5 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

NALP5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

NLRP5

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

NLR family, pyrin domain containing 5

NCBI Organism

Homo sapiens

Background Reference 01

Tschopp J, Martinon F, and Burns K. NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol.2003; 4:95-104.

Background Reference 02

Tian X, Pascal G, and Monget P. Evolution and functional divergence of NLRP genes in mammalian reproductive system. BMC Evol. Biol.2009; 9:202.

Background Reference 03

Tong ZB, Gold L, Pfeiffer KE, et al. Mater, a maternal effect gene required for early embryonic development in mice. Nat. Genet.2000; 26:267-8.

Background Reference 04

Frederick Lo C, Ning X, Gonzales C, et al. Induced expression of death domain genes NALP1 and NALP5 following neuronal injury. Biochem. Biophys. Res. Commun.2008; 366:664-9.