ApoA4 Antibody

ApoA4 Antibody: Apolipoprotein A4 (also known as ApoA-IV) is a plasma protein that is an O-linked glycoprotein after proteolytic processing. ApoA4 is a major constituent of HDL and it also can be found on the surface of newly synthesized chylomicrons. The physiological function of ApoA4 is not completely identified so far, but evidence from several in vitro studies indicate that this apolipoprotein is involved in several steps of the reverse cholesterol transport pathway, which transports cholesterol from peripheral cells back to the liver.

ApoA4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Karathanasis SK, Oettgen P, Haddad IA, et al. Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4) . Proc. Natl. Acad. Sci. USA 1986; 83: 8457-61

Kamboh MI, Friedlaender JS, Ahn YI, et al. A common deletion polymorphism in the apolipoprotein A4 gene and its significance in lipid metabolism. Arterioscler. Thromb. 1994; 14: 656-62

Kronenberg F, Stuhlinger M, Trenkwalder E, et al. Low apolipoprotein A-IV plasma concentrations in men with coronary artery disease. J. Am. Coll. Cardiol. 2000; 36:751-7.

Von Eckardstein A, Huang Y, Wu S, et al. Lipoproteins containing apolipoprotein A-IV but not apolipoprotein A-I take up and esterify cell-derived cholesterol in plasma. Arterioscler. Thromb. Vasc. Biol. 1995; 15:1755-63.