What is the catalog number for HVCN1 Antibody?

The catalog number for HVCN1 Antibody is 5875.

What sizes are available for HVCN1 Antibody?

HVCN1 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does HVCN1 Antibody come in?

HVCN1 Antibody is available in 2 different pack sizes.

Is HVCN1 Antibody in stock?

HVCN1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

HVCN1 Antibody

Product Specifications

Background

HVCN1 Antibody: HVCN1 (hydrogen voltage-gated channel 1), a voltage gated proton channel protein that is highly expressed in immune tissues, mediates the proton conductances required by phagocytic leukocytes for the oxidative burst that underlies microbial killing. HVCN1 moderates the voltage-dependent proton permeability of excitable membranes by allowing the flow of protons in accordance to their electrochemical gradient. HVCN1 is sensitive to zinc ions, and can be inhibited by them. HVCN1 may represent a new therapeutic target for B cell malignancies on continued signaling via the B cell antigen receptor.

NCBI Gene ID

84329

Swiss Prot

Q96D96

Accession Number

NP_115745

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

HVCN1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1406 - Mouse Spleen Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Chicken: (71%)

Buffer

HVCN1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

HVCN1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

HVCN1

Positive Control 2

Cat. No. 1306 - Human Spleen Tissue Lysate

NCBI Official Name

Hydrogen voltage-gated channel 1

NCBI Organism

Homo sapiens

Background Reference 01

Ramsey IS, Moran MM, Chong JA, et al. A voltage gated proton-selective channel lacking the pore domain. Nature2006; 440:1213-6.

Background Reference 02

Sasaki M, Takagi M, and Okamura Y. A voltage sensor-domain protein is a voltage-gated proton channel. Science2006; 312: 589-92.

Background Reference 03

Morgan D, Capasso M, and Musset B. Voltage-gated proton channels maintain pH in human neutrophils during phagocytosis. Proc. Natl. Acad. Sci. USA2009; 106:18022-7.

Background Reference 04

Capasso M, Bhamrah MK, Henley T, et al. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. Nat. Immunol.2010;11:265-72.