ZEB1 Antibody

Product Specifications

Background

ZEB1 Antibody: ZEB1, initially identified as the delta-crystallin enhancer binding protein delta EF1, is a DNA-binding protein that binds to a modified E-box sequence and has been implicated in postgastrulation embryogenesis. ZEB1 binds to the promoter of several hemapoietic genes, including interleukin-2, CD4, GATA-3, and alpha-integrin, and mice in which ZEB1 has been targeted show thymic atrophy, and severe defects in lymphocyte differentiation. Recent evidence suggests that ZEB1 also regulates the accumulation of adipose tissue and may play a role in obesity. Mutations in this gene have been associated with late-onset Fuchs endothelial corneal dystrophy.

NCBI Gene ID

6935

Swiss Prot

P37275

Accession Number

NP_110378

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

ZEB1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Buffer

ZEB1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

ZEB1 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

Multiple isoforms of ZEB1 are known to exist.

Symbol

ZEB1

Positive Control 2

Cat. No. 10-201 - Human Liver Tissue Slide

Positive Control 3

Cat. No. 17-001 - HeLa Cell Slide

NCBI Official Name

Zinc finger E-box binding homeobox 1

NCBI Organism

Homo sapiens

Background Reference 01

Funahashi J, Sekido R, Murai K, et al. Delta-crystallin enhancer protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis. Dev.1993; 119:433-46.

Background Reference 02

Postigo AA and Dean DC. Independent repressor domains in ZEB regulate muscle and T-cell differentiation. Mol. Cell Biol.1999; 19:7961-71.

Background Reference 03

Saykally JN, Dogan S, Cleary MP, et al. The ZEB1 transcription factor is a novel repressor of adiposity in female mice. PLos One2009; 4:e8460.

Background Reference 04

Mehta JS, Vithana EN, Tan DT, et al. Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset Fuchs endothelial corneal dystrophy. Invest. Opthalmol. Vis. Sci.2008; 49:184-8.

Other Product Names

ZEB1 Antibody: BZP, TCF8, AREB6, FECD6, NIL2A, PPCD3, ZFHEP, ZFHX1A, DELTAEF1, Zinc finger E-box-binding homeobox 1, NIL-2-A zinc finger protein, TCF-8

Tested Applications

ELISA, WB, IHC-P, ICC, IF

Protein ID

55957123

Physical Properties

Liquid

Available Sizes

Curated Selection

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