Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

C-raf Antibody

Product Specifications

Background

C-raf Antibody: C-raf is the cellular homolog of viral raf gene (v-raf) and encodes a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases. Once activated, C-raf phosphorylates and activates the protein kinases MEK1 and MEK2, which in turn phosphorylate and activate the serine/threonine specific protein kinases, ERK1 and ERK2. These activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.

NCBI Gene ID

5894

Swiss Prot

P04049

Accession Number

NP_002871

Host

Chicken

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

C-raf Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1202 - A431 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (84%)

Buffer

C-raf Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

C-raf antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=5779

Fragment

IgY

Symbol

RAF1

NCBI Official Name

V-raf-1 murine leukemia viral oncogene homolog 1

NCBI Organism

Homo sapiens

Background Reference 01

Howe LR, Leevers SJ, Gomez N, et al. Activation of the MAP kinase pathway by the protein kinase raf. Cell1992; 71:335-42.

Background Reference 02

Chang F, Steelman LS, Shelton JG, et al. Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway. Int. J. Oncol.2003; 22:469-80.

Background Reference 03

Pandit B, Sarkozy A, Pennacchio LA, et al. Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Nat. Genet.2007; 39:1007-12.

Other Product Names

C-raf Antibody: NS5, CRAF, Raf-1, c-Raf, RAF, Proto-oncogene c-RAF, cRaf

Tested Applications

ELISA, WB

Protein ID

4506401

Physical Properties

Liquid

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

BUBBLE PADDLE RESERVOIR, Sealed Bearing Drive Shaft, Delrin Reservoir, Sculpted Bottom for 8 Pipette Tips, Includes 1 Bubble Paddle, Black Anodized Aluminum, 9 Bubbles/Paddle, Mixes 65mL, Powered by VP 766A-5A Motor Control Unit
VP 758A-3 1 Each

BUBBLE PADDLE RESERVOIR, Sealed Bearing Drive Shaft, Delrin Reservoir, Sculpted Bottom for 8 Pipette Tips, Includes 1 Bubble Paddle, Black Anodized Aluminum, 9 Bubbles/Paddle, Mixes 65mL, Powered by VP 766A-5A Motor Control Unit

Ask
View Details
Rat ADP/Acrp30 Antibody Pair Set
MBS2577784-01 1 Pair

Rat ADP/Acrp30 Antibody Pair Set

Ask
View Details
Rat ADP/Acrp30 Antibody Pair Set
MBS2577784-02 5x 1 Pair

Rat ADP/Acrp30 Antibody Pair Set

Ask
View Details
PIGS Antibody
59-722 400 µL

PIGS Antibody

Ask
View Details
6-phosphogluconolactonase (PGLS) Human ELISA Kit
B1212 96 Tests

6-phosphogluconolactonase (PGLS) Human ELISA Kit

Ask
View Details
GULP (h)-PR
sc-62427-PR 10 µM, 20 µL

GULP (h)-PR

Ask
View Details