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SIRT5 Antibody

Product Specifications

Background

SIRT5 Antibody: The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT5 localizes to mitochondria, deacetylates carbamoyl phosphate synthetase 1, and is involved in the regulation of the urea cycle.

NCBI Gene ID

23408

Swiss Prot

Q9NXA8

Accession Number

NP_036373

Host

Chicken

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

SIRT5 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1202 - A431 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Rat: (94%), Bovine: (88%), Chicken: (82%)

Buffer

SIRT5 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SIRT5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgY

Symbol

SIRT5

NCBI Official Name

Sirtuin 5

NCBI Organism

Homo sapiens

Background Reference 01

Salminen A. SIRT1: regulation of longevity via autophagy. Cell Signal2009; 21:1356-60.

Background Reference 02

Afshar G and Murnane JP. Characterization of a human gene with sequence homology to Saccharomyces cerevisiae Sir 2. Gene1999; 234:161-8.

Background Reference 03

Guarente L. Sirtuins as potential targets for metabolic syndrome. Nature2006; 444:868-74.

Background Reference 04

Vaziri H, Dessain SK, Ng Eaton E, et al. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase. Cell2001; 107:149-59.

Other Product Names

SIRT5 Antibody: SIR2L5, SIR2L5, NAD-dependent protein deacylase sirtuin-5, mitochondrial, Regulatory protein SIR2 homolog 5

Tested Applications

ELISA, WB

Protein ID

6912664

Physical Properties

Liquid

Available Sizes

Frequently Asked Questions

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