What is the catalog number for PIAS1 Antibody?

The catalog number for PIAS1 Antibody is 5741.

What sizes are available for PIAS1 Antibody?

PIAS1 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does PIAS1 Antibody come in?

PIAS1 Antibody is available in 2 different pack sizes.

Is PIAS1 Antibody in stock?

PIAS1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

PIAS1 Antibody

Product Specifications

Background

PIAS1 Antibody: The PIAS proteins (protein inhibitor of activated STAT) play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS1. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS1 binds specifically to STAT1, inhibiting STAT1-mediated gene activation and also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS1 is a potent co-activator for CP2c-mediated alpha-globin expression in erythroid cells.

NCBI Gene ID

8554

Swiss Prot

O75925

Accession Number

NP_057250

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction

Purification

PIAS1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1305 - Human Kidney Tissue Lysate

Concentration

1 mg/mL

Buffer

PIAS1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PIAS1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

PIAS1

NCBI Official Name

Protein inhibitor of activated STAT, 1

NCBI Organism

Homo sapiens

Background Reference 01

Liu B, Liao J, Rao X, et al. Inhibition of Stat1-mediated gene activation by PIAS1. Proc. Natl. Acad. Sci. USA1998; 95: 10626-31.

Background Reference 02

Shuai K and Liu B. Regulation of gene-activation pathways by PIAS proteins in the immune system. Nat. Rev. Immunol.2005; 5:593-605.

Background Reference 03

Kang HC, Chae JH, Jeon J, et al. PIAS1 regulates CP2c localization and active promoter complex formation in erythroid cell-specific {alpha}-globin expression. Nuc. Acids Res.2010 Apr 26.