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TCC52 Antibody

Product Specifications

Background

TCC52 Antibody: Cancer-testis (CT) antigens are a type of antigen whose expression is highly restricted, primarily in normal testis, but aberrantly in different tumor types. Their immunogenicity in cancer patients makes them prime targets for immunotherapy of human tumors. One such CT antigen is TCC52, a novel centrosomal protein. TCC52 is a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The normal biological function of this protein is not known at this time.

NCBI Gene ID

25853

Swiss Prot

Q5T6F0

Accession Number

NP_056212

Host

Chicken

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

TCC52 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1210 - HEK293 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (87%)

Buffer

TCC52 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TCC52 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgY

Symbol

DCAF12

Positive Control 2

Cat. No. 17-010 - HEK293 Cell Slide

NCBI Official Name

DDB1 and CUL4 associated factor 12

NCBI Organism

Homo sapiens

Background Reference 01

Scanlan M, Simpson A, and Old L. The cancer/testis genes: review, standardization, and commentary. Cancer Immun.2004; 4:1-15.

Background Reference 02

Xia L, Li Y, Yang D, et al. Identification of new centrosome proteins by autoimmune patient sera. Sci. China C. Life Sci.2007; 50:194-202.

Background Reference 03

Li S, Hu X, Cui S, et al. Novel centrosome protein, TCC52, is a cancer-testis antigen. Cancer Sci.2008; 11:2274-9.

Other Product Names

TCC52 Antibody: CT102, TCC52, WDR40A, KIAA1892, DDB1- and CUL4-associated factor 12, Centrosome-related protein TCC52

Tested Applications

ELISA, WB, ICC

Protein ID

22218619

Physical Properties

Liquid

Available Sizes

Curated Selection

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