RANBP10 Antibody
Product Specifications
Background
RANBP10 Antibody: The RAN binding protein 10 (RANBP10) is a cytoplasmic guanine nucleotide exchange factor that shares high sequence similarity to the MET-interacting protein RANBP9. RANBP10 is expressed in the cytoplasm of mature megakaryocytes (MKs) and platelets where it localizes to polymerized noncentrosomal microtubules. RANBP10 possesses guanine nucleotide exchange factor activity towards RAN, a GTPase involved in nucleocytoplasmic traffic, spindle formation at mitosis, and nuclear envelope assembly during telophase, suggesting that RANBP10 may also be involved in these activities. RANBP10 depletion in vitro caused the disturbance of polymerized filaments in MKs and platelets in RANBP10-null mice exhibited disorders in microtubule filament numbers and localization, indicating that RANBP10 may play a significant role in maintaining microtubule dynamics.
NCBI Gene ID
57610
Swiss Prot
Q6VN20
Accession Number
EAW83167
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
RANBP10 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1375 - Human Skeletal Muscle Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Bovine: (93%), Mouse: (87%)
Buffer
RANBP10 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
RANBP10 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=5665
Fragment
IgG
Symbol
RANBP10
NCBI Official Name
RAN binding protein 10
NCBI Organism
Homo sapiens
Background Reference 01
Wang D, Zaibo Li, Schoen SR, et al. A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/ERK signaling. Biochem. Biophys. Res. Comm.2004; 313:320-6.
Background Reference 02
Schulze H, Dose M, Korpal M, et al. RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. J. Biol. Chem.2008; 283:14109-19.
Background Reference 03
Dasso M. The Ran GTPase: theme and variations. Curr. Biol.2002; R502-8.
Background Reference 04
Kunert S, Meyer I, Fleischhauer S, et al. The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation. Blood2009; 114:5532-40.
Other Product Names
RANBP10 Antibody: KIAA1464, Ran-binding protein 10, RanBP10
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
119603573
Physical Properties
Liquid
Available Sizes
Curated Selection
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