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SOX2 Antibody

Product Specifications

Background

SOX2 Antibody: SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. SOX2 is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. The role of SOX2 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing SOX2 and the transcription factors POU5F1, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. Other experiments have shown that iPS cells could be generated using expression plasmids expressing POU5F1, SOX2, KlfF4 and c-Myc, eliminating the need for virus introduction.

NCBI Gene ID

6657

Swiss Prot

P48431

Accession Number

NP_003097

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis, Stem Cell

Purification

SOX2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1282 - 3T3 (NIH) Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Sheep: (100%), Chicken: (100%), Horse: (83%), Pig: (100%)

Buffer

SOX2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SOX2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=5583

Fragment

IgG

Symbol

SOX2

Positive Control 2

Cat. No. 17-201 - 3T3/BALB Cell Slide

NCBI Official Name

SRY (sex determining region Y) -box 2

NCBI Organism

Homo sapiens

Background Reference 01

Hever AM, Williamson KA, and van Heyningen V. Developmental malformations of the eye: the role of PAX6, SOX2 and OTX2. Clin. Genet.2006; 69:459-70.

Background Reference 02

Carpenter MK, Rosler E, and Rao MS. Characterization and differentiation of human embryonic stem cells. Cloning Stem Cells2003; 5:79-88.

Background Reference 03

Takahashi K and Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell2006; 1263:663-76.

Background Reference 04

Okita K, Nakagawa M, Hyenjong H, et al. Generation of mouse induced pluripotent stem cells without viral vectors. Science2008; 322:949-53.

Other Product Names

SOX2 Antibody: ANOP3, MCOPS3, Transcription factor SOX-2

Tested Applications

ELISA, WB, ICC, IHC-P, IF

Protein ID

28195386

Physical Properties

Liquid

Available Sizes

Curated Selection

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