VLK Antibody
Product Specifications
Background
VLK Antibody: VLK was identified as a novel protein kinase that was induced after the differentiation of cultured embryonic stem cells into mesendoderm. It has no homologs in invertebrates, but is highly conserved in vertebrate species although it does not belong to any known protein kinase groups. VLK is initially expressed in E-cadherin-positive anterior visceral endoderm and mesendoderm, but its expression is later confined to E-cadherin-negative mesenchyme. It is enriched in the Golgi apparatus and is thought to regulate the rate of protein export from the Golgi. Targeted disruption of VLK in mice leads to a defect in lung development and neonatal lethality. It has been suggested that mutations in VLK may be associated with the allergic condition atopy.
NCBI Gene ID
91461
Swiss Prot
Q5RJI4
Accession Number
NP_612379
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Stem Cell
Purification
VLK Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1302 - Human Lung Tissue Lysate
Concentration
1 mg/mL
Buffer
VLK Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
VLK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=5561
Fragment
IgG
Symbol
Pkdcc
Positive Control 2
Cat. No. 1205 - Jurkat Cell Lysate
NCBI Official Name
Protein kinase domain containing, cytoplasmic
NCBI Organism
Homo sapiens
Background Reference 01
Kinoshita M, Era T, Jakt LM, et al. The novel protein kinase Vlk is essential for stromal function of mesenchymal cells. Development2009; 136:2069-79.
Background Reference 02
Castro-Giner F, Bustamante M, Ramon Gonzalez J, et al. A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS) . BMC Med. Genet.2009; 10:128.
Other Product Names
VLK Antibody: Vlk, MAd1, Adtk1, ESTM17, Sgk493, X83346, AI115348, AW548124, Vlk, Protein kinase domain-containing protein, cytoplasmic, Protein kinase-like protein SgK493
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
238636897
Physical Properties
Liquid
Available Sizes
Curated Selection
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