PICALM Antibody

Product Specifications

Background

PICALM Antibody: PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimer's disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP) .

NCBI Gene ID

8301

Swiss Prot

Q13492

Accession Number

NP_009097

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

PICALM Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1287 - EL4 Cell Lysate

Concentration

1 mg/mL

Buffer

PICALM Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

PICALM antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

PICALM

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Phosphatidylinositol binding clathrin assembly protein

NCBI Organism

Homo sapiens

Background Reference 01

Tebar F, Bohlander SK, and Sorkin A. Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin mediated traffic. Mol. Biol. Cell1999; 10:2687-702.

Background Reference 02

Caudell D and Aplan PD. The role of CALM-AF10 gene fusion in acute leukemia. Leukemia2008; 22:678-85.

Background Reference 03

Harel A, Wu F, Mattson MP, et al. Evidence for CALM in directing VAMP2 trafficking. Traffic2008; 9:417-29.

Background Reference 04

Harold D, Abraham R, Hollingworth P, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat. Genet.2009; 41:1088-93.