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RHBDD2 Antibody

Product Specifications

Background

RHBDD2 Antibody: The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. Little is known about the role of RHBDD2. Its overexpression in breast carcinoma appears to be an indicator of poor prognosis and may play a role in breast cancer progression. The related proteins RHBDD1 and RHBDD3 are both involved in the regulation of apoptosis, suggesting that RHBDD2 may also be involved in the modulation of apoptotic activity.

NCBI Gene ID

57414

Swiss Prot

Q6NTF9

Accession Number

NP_001035546

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis

Purification

RHBDD2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1462 - Rat Lung Tissue Lysate

Concentration

1 mg/mL

Buffer

RHBDD2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

RHBDD2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

RHBDD2

NCBI Official Name

Rhomboid domain containing 2

NCBI Organism

Homo sapiens

Background Reference 01

Koonin EV, Makarova KS, Rogozin IB, et al. The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple horizontal gene transfers. Genome Biol.2003; 4:R19.

Background Reference 02

Abba MC, Sun H, Hawkins KA, et al. Breast cancer molecular signatures as determined by SAGE: correlation with lymph node status. Mol. Cancer Res.2007; 5:881-90.

Background Reference 03

Abba MC, Lacunza E, Nunez MI, et al. Rhomboid domain containing 2 (RHBDD2) : a novel cancer-related gene over-expressed in breast cancer. Biochim. Biophys. Acta2009; 1792:988-97.

Background Reference 04

Wang Y, Guan X, Fok KL, et al. A novel member of the rhomboid family, RHBDD1, regulates BIK-mediated apoptosis. Cell Mol. Life Sci.2008; 65:3822-9.

Other Product Names

RHBDD2 Antibody: NPD007, RHBDL7, Rhomboid domain-containing protein 2

Tested Applications

ELISA, WB, IF

Protein ID

94818790

Physical Properties

Liquid

Available Sizes

Frequently Asked Questions

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