What is the catalog number for SIPA1L3 Antibody?

The catalog number for SIPA1L3 Antibody is 5495.

What sizes are available for SIPA1L3 Antibody?

SIPA1L3 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does SIPA1L3 Antibody come in?

SIPA1L3 Antibody is available in 2 different pack sizes.

Is SIPA1L3 Antibody in stock?

SIPA1L3 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

SIPA1L3 Antibody

Product Specifications

Background

SIPA1L3 Antibody: Signal-induced proliferation associated-like protein 2 (SIPA1L3) is a member of the SIPA1 family of RapGAPs. SIPA1L3 was cloned as a novel molecular component of tight junctions and adherens junctions, suggesting that may function to balance Rap1 by counteracting RapGEFs. Recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is possible that SIPA1L3 plays other roles development and cell proliferation.

NCBI Gene ID

23094

Swiss Prot

O60292

Accession Number

NP_055888

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer

Purification

SIPA1L3 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1220 - SK-N-SH Cell Lysate

Concentration

1 mg/mL

Buffer

SIPA1L3 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SIPA1L3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

SIPA1L3

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Signal-induced proliferation-associated 1 like 3

NCBI Organism

Homo sapiens

Background Reference 01

Minato N and Hattori M. SPA-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis. Cancer Sci.2009; 100:17-23.

Background Reference 02

Matsuda M, Kobayashi Y, Masuda S, et al. Identification of adherences junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning. Exp. Cell Res.2008; 314:939-49.

Background Reference 03

Ishida D, Kometani K, Yang H, et al. Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell2003; 4:55-65.