PLEKHM2 Antibody

PLEKHM2 Antibody: PLEKHM2, also known as SKIP, is a member of the M family of Pleckstrin homology domain-containing proteins. While little is known of PLEKHM2, a recent study examining differential gene expression in human hematopoietic stem cells has shown it to be specifically expressed in stem cells, suggesting that PLEKHM2 may play a role in erythroid commitment and development. Other studies have shown that PLEKHM2 is required for interaction with the Salmonella virulence factor SifA for Salmonella pathogenesis, suggesting that PLEKHM2 has cellular roles other than in the developing embryo.

PLEKHM2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Liu X-L, Yuan J-Y, Zhang J-W, et al. Differential gene expression in human hematopoietic stem cells specified toward erythroid, megakaryotic, and granulocytic lineage. J. Leuk. Biol.2007; 82:986-1002.

Diacovich L, Dumont A, Lafitte D, et al. Interaction between the SifA virulence factor and its host target SKIP is essential for Salmonella pathogenesis. J. Biol. Chem.2009; 284:33151-60.

PLEKHM2 Antibody: SKIP, KIAA0842, SKIP, Pleckstrin homology domain-containing family M member 2, Salmonella-induced filaments A and kinesin-interacting protein, PH domain-containing family M member 2