NALP3 Antibody

NALP3 Antibody: NALP3, a member of Nod-like receptors, has a crucial role in inflammation and immunity and may be a proximal sensor of cellular stress and danger signals. NALP3 forms a caspase-1 activating molecular complex termed the inflammasome. The inflammasome allows activation of IL-1β, the key player of the inflammation and fever. NALP3 gene encodes a pyrin like protein which contains a pyrin domain, a nucleotide binding site (NBS) domain, and a leucine rich repeat (LRR) motif. NALP3 protein interacts with apoptosis associated speck like protein containing a CARD and may function as an inducer of apoptosis and an activator of NF-κB signaling. Defects in NALP3 have been associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID) . Recently, NALP3 has been shown to be a key factor in the lung pathology for the body's SARS-CoV-2 response. Inhibition of the NLRP3 inflammasome pathway reduces the inflammatory profile of infected cells as well as reducing immune cell infiltration and enhancing tissue recovery to homeostasis. The goal of this treatment is to reduce symptoms of Covid19 infection in the lungs.

NALP3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Human NALP3 has 6 isoforms, including isoform 1 (1036aa, 118.2kD), isoform 2 (922aa, 106kD), isoform 3 (719aa, 83.5kD), isoform 4 (979aa, 111.9kD), isoform 5 (979aa, 112.3kD), and isoform 6 (1016aa, 116kD) . Mouse NALP3 has 4 isoforms, including isoform 1 (1033aa, 118.3kD), isoform 2 (976aa, 112.1kD), isoform 3 (976aa, 112kD), and isoform 4 (829aa, 95.7kD) . Rat NALP3 has 1 isoform (1035aa, 118.5kD) . 5447 can detect NALP3 in human, mouse, and rat.

NALP3 Antibody: AII, AVP, FCU, MWS, FCAS, CIAS1, NALP3, C1orf7, CLR1.1, PYPAF1, AGTAVPRL, NACHT, LRR and PYD domains-containing protein 3, Cold autoinflammatory syndrome 1 protein