Prosapip2 Antibody
Product Specifications
Background
Prosapip2 Antibody: Prosapip2 (TBKBP1) is essential for signal transduction during viral infection thus plays a major role in the TNF/NF-κ B pathway. It is an adaptor protein that constitutively binds TBK1 (TANK-binding kinase) and IKBKE and may play a role in antiviral innate immunity. Prosapip2 is a 615 amino acid adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It has a ubiquitous expression with highest levels in ovary, followed by the neuronal system. Prosapip2 binds to TBK1 and helps in the activation of IRF3 which controls the expression of antiviral genes during infection. Recent studies show that Prosapip2 is an interaction partner of ProSAP2/Shank3 and actin, suggesting a role as a linker molecule between postsynaptic density and the cytoskeleton.
NCBI Gene ID
9755
Swiss Prot
A7MCY6
Accession Number
NP_055541
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Innate Immunity
Purification
Prosapip2 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1464 - Rat Liver Tissue Lysate
Concentration
1 mg/mL
Buffer
Prosapip2 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Prosapip2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=5397
Fragment
IgG
Symbol
TBKBP1
NCBI Official Name
TBK1 binding protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Bouwmeester T, Bauch A, Ruffner H, et al. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat. Cell Biol.2004; 6:97-105
Background Reference 02
Ryzhakov G and Randow F. SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK. EMBO J.2007; 26:3180-90.
Background Reference 03
Meffert MK, Chang JM, Wiltgen BJ, et al. NF-kappa B functions in synaptic signaling and behavior. Nat. Neurosci.2003; 6:1072-78.
Background Reference 04
Liebau S, Proepper C, Schmidt T, et al. ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3. Biochem. Biophys. Res Commun.2009; 385:460-5.
Other Product Names
Prosapip2 Antibody: SINTBAD, ProSAPiP2, KIAA0775, SINTBAD, TANK-binding kinase 1-binding protein 1, TBK1-binding protein 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
7662302
Physical Properties
Liquid
Available Sizes
Curated Selection
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