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SCARA5 Antibody

Product Specifications

Background

SCARA5 Antibody: Scavenger receptor class A member 5 (SCARA5), also known as TESR, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARA5 is a cell-surface receptor that contains the collagen-like domain and N-terminal scavenger receptor cysteine rich domain typical of the class A scavenger receptor subfamily. Unlike other class A receptors, SCARA5 does not endocytose acetylated or oxidized low density lipoprotein. Instead, SCARA5 binds serum ferritin and mediates its endocytosis from the cell surface, indicating SCARA5 may play a role in non-transferrin iron delivery.

NCBI Gene ID

286133

Swiss Prot

Q6ZMJ2

Accession Number

NP_776194

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

SCARA5 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1306 - Human Spleen Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Mouse: (88%), Chicken: (86%), Rat: (80%)

Buffer

SCARA5 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

SCARA5 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=5259

Fragment

IgG

Specificity

At least four isoforms of SCARA5 are known to exist; this antibody will detect all four isoforms.

Symbol

SCARA5

Positive Control 2

Cat. No. 17-011 - Hep G2 Cell Slide

NCBI Official Name

Scavenger receptor class A, member 5 (putative)

NCBI Organism

Homo sapiens

Background Reference 01

Greaves DR, Gough PJ, and Gordon S. Recent progress in defining the role of scavenger receptors in lipid transport, atherosclerosis and host defence. Curr. Op. Lipid. 1998; 9:425-32.

Background Reference 02

Jiang Y, Oliver P, Davies KE, et al. Identification and characterization of murine SCARA5, a novel class A scavenger receptor that is expressed by populations of epithelial cells. J. Biol. Chem. 2006; 281:11834-45.

Background Reference 03

Li JY, Paragas N, Ned RM, et al. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev. Cell 2009; 16:35-46.

Other Product Names

SCARA5 Antibody: Tesr, NET33, Scavenger receptor class A member 5, Scavenger receptor hlg

Tested Applications

ELISA, WB, ICC, IF

Protein ID

47271477

Physical Properties

Liquid

Available Sizes

Curated Selection

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