Swine H1N1 Neuraminidase Antibody

Product Specifications

Background

Swine H1N1 Neuraminidase Antibody: Influenza A virus is a major public health threat, killing more than 30, 000 people per year in the USA. In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States. The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic. Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible Neuraminidase (NA) surface proteins. The Hemagglutinin protein facilitates viral attachment while Neuraminidase is involved in viral release. These proteins also elicit immune responses that prevent infection or independently reduce viral replication. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin. The distinct antigenic properties of the new swine influenza virus compared with seasonal influenza A (H1N1) virus suggest that human immunity against new swine influenza virus is limited, although the age distribution of reported cases suggests some degree of protection in older age groups.

Swiss Prot

C4AL28

Accession Number

ACQ76308

Host

Rabbit

Reactivity

Virus

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease

Purification

Swine H1N1 Neuraminidase Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Buffer

Swine H1N1 Neuraminidase Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Swine H1N1 Neuraminidase antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

This antibody is specific for the novel swine influenza Neuraminidase and will not recognize the corresponding Neuraminidase sequence from the seasonal H1N1 influenza (A/Georgia/20/2006 (H1N1) ) . Will not cross-react with peptide corresponding to the seasonal influenza (H1N1) Neuraminidase.

Applications Notes

Neuraminidase antibody can be used for the detection of the Neuraminidase protein from the H1N1 strain of swine influenza A in ELISA. It will detect 2 ng of free peptide at 1 μ g/mL

Symbol

NCBI Official Name

Neuraminidase

NCBI Organism

Influenza A virus (A/California/14/2009 (H1N1) )

Background Reference 01

Thompson WW, Shay DK, Weintraub, et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA2003; 289:179-186.

Background Reference 02

Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team, Dawood FS, Jain S, et al. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N. Engl. J. Med.2009; 360:2605-15.