MC4R Antibody

Product Specifications

Background

MC4R Antibody: The melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity; activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.

NCBI Gene ID

4160

Swiss Prot

P32245

Accession Number

NP_005903

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Obesity

Purification

MC4R Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1463 - Rat Brain Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Pig: (79%)

Buffer

MC4R Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

MC4R antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

MC4R

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Melanocortin 4 receptor

NCBI Organism

Homo sapiens

Background Reference 01

Gantz I, Miwa H, Konda Y, et al. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J. Biol. Chem.1993; 268:15174-9.

Background Reference 02

Vongs A, Lynn NM, and Rosenblum CI. Activation of MAP kinase by MC4-R through PI3 kinase. Regul. Pept.2004; 120:113-8.

Background Reference 03

Cone H. Anatomy and regulation of the central melanocortin system. Nat. Neurosci.2005; 8:571-8.

Background Reference 04

Chai B, Li J-Y, Zhang W, et al. Melanocartin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling. Peptides2009; 30:1098-10