Transthyretin Antibody

Product Specifications

Background

Transthyretin Antibody: Transthyretin is a tetrameric carrier protein that transports thyroid hormones in the plasma and cerebrospinal fluid, and retinol (vitamin A) in the plasma. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart. The diseases caused by mutations include familial amyloidotic polyneuropathy, euthyroid hyperthyroxinemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, and carpal tunnel syndrome. It has also been suggested that Transthyretin plays an important role in the maintenance of normal cognitive processes during aging, neuropeptide processing and nerve regeneration. It has also been linked to several pathological conditions including Parkinson's disease, schizophrenia, and depression.

NCBI Gene ID

7276

Swiss Prot

P02766

Accession Number

P02766

Host

Chicken

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

Transthyretin Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1211 - HepG2 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (94%), Sheep: (88%), Rabbit: (82%), Pig: (82%)

Buffer

Transthyretin Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Transthyretin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgY

Symbol

TTR

Positive Control 2

Cat. No. 10-101 - Human Lung Tissue Slide

NCBI Official Name

Transthyretin

NCBI Organism

Homo sapiens

Background Reference 01

Fleming CE, Nunes AF, and Sousa MM. Transthyretin: more than meets the eye. Prog. Neurobiol.2009; 89:266-76.

Background Reference 02

Fleming CE, Saraiva MJ, and Sousa MM. Transthyretin enhances nerve regeneration. J. Neurochem. 2007; 103:831-9.

Background Reference 03

Rite I, Arguelles S, Venero JL, et al. Proteomic identification of biomarkers in the cerebrospinal fluid in a rat model of nigrostriatal dopaminergic degeneration. J. Neurosci. Res. 2007; 85:3607-18.