RUNX1 Antibody

Product Specifications

Background

RUNX1 Antibody: RUNX1 is one of three mammalian RUNX genes that control multiple aspects of embryonic development and are responsible for the pathogenesis of many human diseases. RUNX1 plays major roles in the development of nociceptive sensory neurons in addition to hematopoietic stem cells (HSC) with the exception of the erythroid lineage. During development, Notch signals mediate RUNX1 induction with SCL/GATA/Ets factors, and Wnt signals potentially cooperate with RUNX1 to facilitate adult HSC expansion via cooperative induction of cyclin D, cdk4, and other cell cycle regulators. In turn, RUNX1 regulates cell cycle transitions dependent on functional/physical interactions with other proteins such as HDAC1 and -3, mSin3A, p300, SMAD proteins, and LEF/TCF.

NCBI Gene ID

861

Swiss Prot

Q01196

Accession Number

AAI36381

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

RUNX1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1207 - Raji Cell Lysate

Concentration

1 mg/mL

Buffer

RUNX1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

RUNX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

RUNX1

NCBI Official Name

Runt-related transcription factor 1

NCBI Organism

Homo sapiens

Background Reference 01

Lund AH and van Lohuizen M. RUNX: a trilogy of cancer genes. Cancer Cell2002; 1:213-5.

Background Reference 02

Inoue K, Shiga T, and Ito Y. Runx transcription factors in neuronal development. Neur. Dev.2008; 3:20.

Background Reference 03

North TE, Stacy T, Matheny CJ, et al. Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells. Stem Cells2004; 22:158-68.

Background Reference 04

Lee TI, Jenner RG, Boyer LA. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell2006; 125:301-13.

Other Product Names

RUNX1 Antibody: AML1, CBFA2, EVI-1, AMLCR1, PEBP2aB, AML1-EVI-1, AML1, Runt-related transcription factor 1, Acute myeloid leukemia 1 protein, CBF-alpha-2