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FNIP2 Antibody

Product Specifications

Background

FNIP2 Antibody: FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship.

NCBI Gene ID

57600

Swiss Prot

Q9P278

Accession Number

NP_065891

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

FNIP2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1467 - Rat Skeletal Muscle Tissue Lysate

Concentration

1 mg/mL

Buffer

FNIP2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

FNIP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=5045

Fragment

IgG

Specificity

Multiple isoforms of FNIP2 are known to exist. This antibody is predicted to not cross-react with FNIP1.

Symbol

FNIP2

NCBI Official Name

Folliculin interacting protein 2

NCBI Organism

Homo sapiens

Background Reference 01

Hasumi H, Baba M, Hong S-B, et al. Identification and characterization of a novel folliculin-interacting protein FNIP2. Gene2008; 415:60-7.

Background Reference 02

Takagi Y, Kobayashi T, Shiono M, et al. Interaction of folliculin (Birt-Hogg-Dube gene product) with novel Fnip1-like (FnipL/Fnip2) protein. Oncogene2008; 27:5339-47.

Background Reference 03

Vocke CD, Yang Y, Pavlovich CP, et al. High frequency of somatic frameshift BHD mutations in Birt-Hogg-Dube-associated renal tumors. J. Natl. Cancer Inst.2005; 97:931-5.

Background Reference 04

Baba M, Hong SB, Sharma M, et al. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc. Natl. Acad. Sci. USA2006; 103:15552-7.

Other Product Names

FNIP2 Antibody: FNIPL, MAPO1, FNIPL, KIAA1450, Folliculin-interacting protein 2, FNIP1-like protein

Tested Applications

ELISA, WB, IHC-P

Protein ID

154689769

Physical Properties

Liquid

Available Sizes

Curated Selection

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