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KLRA1 Antibody

Product Specifications

Background

KLRA1 Antibody: KLRA1 (also known as Ly49L) is a member of the LY49 family of receptors in Natural Killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA1 is thought to be an activating receptor, inducing DAP12 phosphorylation in response to antibody-mediated cross-linking of KLRA1 on NK cells.

NCBI Gene ID

10748

Swiss Prot

EAW96194

Accession Number

EAW96194

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

KLRA1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1406 - Mouse Spleen Tissue Lysate

Concentration

1 mg/mL

Buffer

KLRA1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

KLRA1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=4999

Fragment

IgG

Specificity

At least three isoforms of KLRA1 are known to exist; this antibody recognizes only the long isoform.

Symbol

KLRA1P

Positive Control 2

Cat. No. 17-010 - HEK293 Cell Slide

NCBI Official Name

Killer cell lectin like receptor A1, pseudogene

NCBI Organism

Homo sapiens

Background Reference 01

Makrigiannis AP, Etzler J, Winkler-Pickett R, et al. Identification of the Ly49L protein: evidence for activating counterparts to inhibitory Ly49 proteins. J. Leuk. Biol.2000; 68:765-71.

Background Reference 02

Smith HR, Karlhofer FM, and Yokoyama WM. Ly-49 multigene family expressed by IL-2-activated NK cells. J. Immunol.1994; 153:1068-79.

Background Reference 03

Brennan J, Mager D, Jefferies W, et al. Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties. J. Exp. Med.1994; 180:2287-95.

Other Product Names

KLRA1 Antibody: Ly49, KLRA#, KLRA1, LY49L, Ly-49L

Tested Applications

ELISA, WB, ICC, IF

Protein ID

119616600

Physical Properties

Liquid

Available Sizes

Curated Selection

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