DISP2 Antibody

Product Specifications

Background

DISP2 Antibody: DISP2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants.

NCBI Gene ID

85455

Swiss Prot

A7MBM2

Accession Number

A7MBM2

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Stem Cell

Purification

DISP2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 11-801 - Human Small Intestine Tissue Slide

Concentration

1 mg/mL

Buffer

DISP2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

DISP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

DISP2 antibody is human specific. At least two isoforms of Disp2 are known to exist. DISP2 antibody is predicted to not cross-react with Disp1 or Disp3.

Symbol

DISP2

NCBI Official Name

Dispatched homolog 2 (Drosophila)

NCBI Organism

Homo sapiens

Background Reference 01

Katoh Y and Katoh M. Identification and characterization of DISP3 gene in silico. Int. J. Oncol. 2005; 26:551-6.

Background Reference 02

Katoh Y and Katoh M. Hedgehog signaling pathway and gastric cancer. Can. Biol. & Ther. 2005; 4:1050-4.

Background Reference 03

Li N, Flynt AS, Kim HR, et al. Dispatched homolog 2 is targeted by miR-214 through a combination of three week microRNA recognition sites. Nuc. Acids Res. 2008; 36:4277-85.