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MettL7B Antibody

Product Specifications

Background

MettL7B Antibody: MettL7B belongs to the methyltransferase superfamily. It is a probable methyltransferase. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Often methylation occurs on nucleic bases in DNA or amino acids in protein structures. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. DNA methylation may be necessary for normal growth from embryonic stages in mammals. When mutant embryonic stem cells lacking the murine DNA methyltransferase gene were introduced to a germline of mice they caused a recessive lethal phenotype. Methylation may also be linked to cancer development as methylation of tumor suppressor genes promotes tumorgenesis and metastasis.

NCBI Gene ID

196410

Swiss Prot

Q6UX53

Accession Number

NP_689850

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

MettL7B Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1320 – Human Colon Tissue Lysate

Concentration

1 mg/mL

Buffer

MettL7B Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

MettL7B antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=4891

Fragment

IgG

Specificity

This MettL7B antibody is predicted to not cross-react with MettL7A.

Symbol

METTL7B

Positive Control 2

Cat. No. 10-901 - Human Spleen Tissue Slide

NCBI Official Name

Methyltransferase like 7B

NCBI Organism

Homo sapiens

Background Reference 01

Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res.2003; 13:2265-70.

Background Reference 02

Li E, Bestor TH, and Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell1992; 69:915-26.

Background Reference 03

Laird PW and Jaenisch R. DNA Methylation and Cancer. Human Molecular Genetics1994; 3:1487-95.

Other Product Names

MettL7B Antibody: ALDI, Methyltransferase-like protein 7B

Tested Applications

ELISA, WB, IHC-P

Protein ID

164663805

Physical Properties

Liquid

Available Sizes

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