MettL7A Antibody

Product Specifications

Background

MettL7A Antibody: MettL7A belongs to the methyltransferase superfamily. It is a probable methyltransferase. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Often methylation occurs on nucleic bases in DNA or amino acids in protein structures. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. DNA methylation may be necessary for normal growth from embryonic stages in mammals. When mutant embryonic stem cells lacking the murine DNA methyltransferase gene were introduced to a germline of mice they caused a recessive lethal phenotype. Methylation may also be linked to cancer development as methylation of tumor suppressor genes promotes tumorgenesis and metastasis.

NCBI Gene ID

25840

Swiss Prot

Q9H8H3

Accession Number

NP_054752

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

MettL7A Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1219 - MCF7 Cell Lysate

Concentration

1 mg/mL

Buffer

MettL7A Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

MettL7A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

At least two isoforms of MettL7A are known to exist. This antibody is predicted to not cross-react with MettL7B.

Symbol

METTL7A

Positive Control 2

Cat. No. 17-012 - MCF7 Cell Slide

NCBI Official Name

Methyltransferase like 7A

NCBI Organism

Homo sapiens

Background Reference 01

Clark HF, Gurney AL, Abaya E, et al. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res.2003; 13:2265-70.