IL-17 Antibody

Product Specifications

Background

IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κ B and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.

NCBI Gene ID

3605

Swiss Prot

Q16552

Accession Number

NP_002181

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

4887

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Recombinant Protein Test (Figure 1) : Anit-IL-17 antibodies (4887) detected human IL-17 recombinant protein at different concentrations Recombinant Protein Test4887

Field of Research

Signal Transduction

Purification

IL-17 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 17-208 - A20 Cell Slide

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (84%), Rat: (81%), Pig: (74%)

Buffer

IL-17 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

IL-17 antibody can be stored at 4˚ C for up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human IL-17 has only one isoform (155aa, 17.5kD) . Mouse IL-17 has one isoform (158aa, 17.5kD) and Rat IL-17 also has one isoform (150aa, 16.9kD) . 4887 can detect human, mouse and rat IL-17.