IL-17 Antibody
Product Specifications
Background
IL-17 Antibody: Interleukin 17 (IL-17) is a family of pro-inflammatory cytokines produced by activated T cells and is thought to have a major role in the initiation and perpetuation of rheumatoid arthritis. IL-17 regulates the activities of NF-κ B and mitogen-activated protein kinases such as ERK and JNK. In addition, IL-17 stimulates the expression of IL-6 and cyclooxygenase-2 and enhances the production of nitric oxide. IL-17-producing T helper cells (TH-17 cells) have been the subject of much attention due to the importance of IL-17 in the pathogenesis of autoimmune inflammation. Because of its role in autoimmune diseases, it is thought that targeting the production and action of IL-17 would be beneficial therapeutically in these diseases.
NCBI Gene ID
3605
Swiss Prot
Q16552
Accession Number
NP_002181
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Recombinant Protein Test (Figure 3) : Anit-IL-17 antibodies (4877) detected human IL-17 recombinant protein at different concentrations.
Recombinant Protein Test4877
Field of Research
Signal Transduction
Purification
IL-17 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1208 - THP-1 Cell Lysate
Concentration
1 mg/mL
Buffer
IL-17 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
IL-17 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Isoform
Human IL-17 has only one isoform (155aa, 17.5kD) . Mouse IL-17 has one isoform (158aa, 17.5kD) and rat IL-17 also has one isoform (150aa, 16.9kD) . 4877 can detect only human isoform, but cannot detect mouse and rat.
Symbol
IL17A
Positive Control 2
Cat. No. 1288 - A20 Cell Lysate
NCBI Official Name
Interleukin 17A
NCBI Organism
Homo sapiens
Background Reference 01
Miossec. Curr. Opin. Rheumatol.2000; 12:181-5.
Background Reference 02
Paunovic et al. Rheumatol.2008; 47:771-6.
Background Reference 03
Steinman. Nat. Med.2007; 13:139-145.
Other Product Names
IL-17 Antibody: IL17, CTLA8, IL-17, IL-17A, IL17, Interleukin-17A, Cytotoxic T-lymphocyte-associated antigen 8
Tested Applications
ELISA, WB
Protein ID
4504651
Physical Properties
Liquid
Available Sizes
Curated Selection
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