Integrin alpha 4 Antibody
Product Specifications
Background
Integrin alpha 4 Antibody: The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
NCBI Gene ID
3676
Swiss Prot
P13612
Accession Number
NP_000876
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Infectious Disease
Purification
Integrin alpha 4 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1466 - Rat Spleen Tissue Lysate
Concentration
1 mg/mL
Buffer
Integrin alpha 4 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Integrin alpha 4 antibody can be stored at 4˚ C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
At least two isoforms are known to exist. The immunogen to this antibody is within the Integrin alpha4 recombinant protein fragment and thus will recognize it.
Symbol
ITGA4
Positive Control 2
Cat. No. 17-005 - Jurkat Cell Slide
NCBI Official Name
Integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
NCBI Organism
Homo sapiens
Background Reference 01
Wegener KL and Campbell ID. Transmembrane and cytoplasmic domains in integrin activation and protein-protein interactions. Mol. Membr. Biol.2008; 25:376-87.
Background Reference 02
Kamata T, Puzon W, and Takada Y. Identification of putative ligand-binding sites of the integrin alpha 4 beta 1 (VLA-4, CD49d/CD29) . Biochem J.1995; 305:945-51.
Background Reference 03
Berlin C, Berg EL, Briskin MJ, et al. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell1993; 74:185-95.
Background Reference 04
Pulido R, Elices MJ, Campanero MR, et al. Functional evidence for three distinct and independently inhibitable adhesion activities mediated by the human integrin VLA-4. Correlation with distinct alpha 4 epitopes. J. Biol. Chem.1991; 266:10241-5.
Other Product Names
Integrin alpha 4 Antibody: IA4, CD49D, Integrin alpha-4, CD49 antigen-like family member D
Tested Applications
ELISA, WB, IF
Protein ID
67191027
Physical Properties
Liquid
Available Sizes
Frequently Asked Questions
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