Gp120 Antibody

Product Specifications

Background

Gp120 Antibody: Human immunodeficiency virus type 1 (HIV-1) entry into target cells is directed by the envelope (Env) glycoproteins, which are present on the surface of HIV-1 virion or infected cells in the form of trimers consisting of gp120/gp41 complexes. The surface subunit, gp120, initiates the entry process by interacting sequentially with the CD4 receptor and a co-receptor CCR5 or CXCR4, thereby inducing a conformational change that allows the transmembrane (TM) gp41 subunit to mediate fusion between viral and target cell membranes. Cleavage of Env into its gp120 and gp41 components is necessary for activation of its fusogenic activity.

NCBI Gene ID

155971

Swiss Prot

Q6BBS3

Accession Number

AAB05604

Host

Goat

Reactivity

Virus

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease

Purification

Gp120 Antibody is affinity chromatography purified via peptide column.

Concentration

1 mg/mL

Buffer

Gp120 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Gp120 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Applications Notes

Gp120 antibody can be used for detection of gp120 by Western blot at 1 μ g/mL.

Symbol

Env

NCBI Official Name

Envelope glycoprotein

NCBI Organism

Human immunodeficiency virus 1

Background Reference 01

Pinter A. Roles of HIV-1 Env variable regions in viral neutralization and vaccine development. Curr. HIV Res.2007; 5:542-53.

Background Reference 02

Alkhatib G and Berger EA. HIV coreceptors: from discovery and designation to new paradigms and promise. Eur. J. Med. Res.2007; 12:375-84.

Other Product Names

Gp120 Antibody: Envelope glycoprotein gp160

Tested Applications

ELISA, WB

Protein ID

1465781

Physical Properties

Liquid

Available Sizes

Curated Selection

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