Wnt10a Antibody

Product Specifications

Background

Wnt10a Antibody: Wnt10a is a member of the Wnt family, a gene family that encodes secreted signaling proteins that play crucial roles in normal development such as regulation of cell fate and patterning during embryogenesis as well as neoplastic transformation. Elevated levels of Wnt10a have been detected in several human tumors and cancer cell lines including colorectal cancer and chronic lymphocytic leukemia and it has been suggested that uncontrolled Wnt signaling may contribute to the defect in apoptosis that characterizes these malignancies. Recently, a mutation in Wnt10a was found to be associated with odonto-onycho-dermal dysplasia, an autosomal recessive ectodermal dysplasia.

NCBI Gene ID

80326

Swiss Prot

Q9GZT5

Accession Number

Q9GZT5

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Signal Transduction, Cancer

Purification

Wnt10a Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1283 - RAW 264.7 Cell Lysate

Concentration

1 mg/mL

Buffer

Wnt10a Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Wnt10a antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

This Wnt10a antibody is predicted to not cross-react with Wnt10b.

Symbol

WNT10A

NCBI Official Name

Wingless-type MMTV integration site family, member 10A

NCBI Organism

Homo sapiens

Background Reference 01

Kelly GM, Lai CJ, and Moon RT. Expression of wnt10a in the central nervous system of developing zebrafish. Dev. Biol. 1993; 158:113-21.

Background Reference 02

Nusse R and Varmus RE. Wnt genes. Cell 1992; 69:1073-87.

Background Reference 03

Kirikoshi H, Sekihara H, and Katoh M. WNT10A and WNT6, clustered in human chromosome 2q35 region head-to-tail manner, are strongly coexpressed in SW480 cells. Biochem. Biophys. Res. Commun. 2001; 283:798-805.