NPTX2 Antibody

Product Specifications

Background

NPTX2 Antibody: Neuronal pentraxin (NPTX) 2 was initially identified as a member of the pentraxin family having high homology to NPTX1. Unlike NPTX1 however, NPTX2 is expressed in testes, pancreas, liver, heart, skeletal muscle as well as brain. NPTX2 possesses the lectin properties common to the pentraxin family, promotes neurite outgrowth, and is rapidly regulated by neuronal activity. NPTX1 and NPTX2 form heterocomplexes that contribute to both activity-independent and -dependent excitatory synaptogenesis. Recently, NPTX2 has been found to be highly upregulated in Parkinsonian substantia nigra and localizes to Lewy bodies and Lewy neurites in sporadic Parkinson's disease (PD), suggesting that it is involved in the pathway dysregulation that underlies PD. This NPTX2 antibody is predicted to be specific to NPTX2 and not recognize NPTX1.

NCBI Gene ID

4885

Swiss Prot

P47972

Accession Number

NP_002514

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

4573

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Independent Antibody Validation in Cell lines (Figure 2) shows similar NPTX2 expression profile in human and mouse cell lines detected by two independent anti-NPTX2 antibodies that recognize different epitopes, 4573 against central domain and 64-234 against another central domain. NPTX2 proteins are detected only in HeLa and HepG2 cell lines by the two independent antibodies. Independent Antibody Validation in Cell lines4573 64-234

Field of Research

Neuroscience

Purification

NPTX2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1403 - Mouse Brain Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Guinea pig: (88%)

Buffer

NPTX2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

NPTX2 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human NPTX2 has one isoform (431aa, 47kD) . Mouse NPTX2 has one isoform (429aa, 47.1kD) and Rat NPTX2 also has one isoform (432aa, 47.4kD) . 4573 can detect human, mouse and rat.

Symbol

NPTX2

Positive Control 2

Cat. No. 1201 – HeLa Cell Lysate

Positive Control 3

Cat. No. 1211 – HepG2 Cell Lysate

Positive Control 4

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Neuronal pentraxin II

NCBI Organism

Homo sapiens

Background Reference 01

Hsu and Perin. Genomics1995; 28:220-7.

Background Reference 02

Tsu et al. J. Neurosci.1996; 16:2463-78.

Background Reference 03

Xu et al. Neuron2003; 39:513-28.

Background Reference 04

Moran et al. Acta Neuropathol.2008; 115:471-8.

Other Product Names

NPTX2 Antibody: NP2, NARP, NP-II, Neuronal pentraxin-2, Neuronal pentraxin II, NP2

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

28195384

Physical Properties

Liquid

Available Sizes

Curated Selection

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