Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

RTP801 Antibody

Product Specifications

Background

RTP801 Antibody: RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC) -dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.

NCBI Gene ID

54541

Swiss Prot

Q9NX09

Accession Number

NP_061931

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

RTP801 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1305 - Human Kidney Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

Buffer

RTP801 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

RTP801 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=4495

Fragment

IgG

Symbol

DDIT4

NCBI Official Name

DNA-damage-inducible transcript 4

NCBI Organism

Homo sapiens

Background Reference 01

Ellisen LW, Ramsayer KD, Johannessen CM, et al. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol. Cell2002; 10:995-1005.

Background Reference 02

Shoshani T, Faerman A, Mett I, et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol. Cell. Biol.2002; 22:2283-93.

Background Reference 03

Wang Z, Malone MH, Thomenius MJ, et al. Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals. J. Biol. Chem.2003; 278:27053-8.

Background Reference 04

Sofer A, Lei K, Johannessen CM, et al. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol. Cell. Biol.2005; 25:5834-45.

Other Product Names

RTP801 Antibody: Dig2, REDD1, REDD-1, RTP801, DNA damage-inducible transcript 4 protein, HIF-1 responsive protein RTP801

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

9506687

Physical Properties

Liquid

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Hus1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
24101114 3 x 1.0 µg

Hus1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

Ask
View Details
Rabbit Polyclonal E2F-4 Antibody [mFluor Violet 500 SE]
NBP2-98787MFV500 0.1 mL

Rabbit Polyclonal E2F-4 Antibody [mFluor Violet 500 SE]

Ask
View Details
1- Bromoheptane 99% For Synthesis
00505 00250 250 mL

1- Bromoheptane 99% For Synthesis

Ask
View Details
MFS12 rabbit pAb
MBS8601518-01 0.1 mL

MFS12 rabbit pAb

Ask
View Details
MFS12 rabbit pAb
MBS8601518-02 0.1 mL (AF405L)

MFS12 rabbit pAb

Ask
View Details
MFS12 rabbit pAb
MBS8601518-03 0.1 mL (AF405S)

MFS12 rabbit pAb

Ask
View Details