Cathelicidin Antibody

Product Specifications

Background

Cathelicidin Antibody: One component of host defense at mucosal surfaces is epithelial-derived antimicrobial peptides. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Finally, Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.

NCBI Gene ID

820

Swiss Prot

P49913

Accession Number

NP_004336

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Innate Immunity

Purification

Cathelicidin Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1306 - Human Spleen Tissue Lysate

Concentration

1 mg/mL

Buffer

Cathelicidin Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Cathelicidin antibody can be stored at 4˚ C, stable for up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

CAMP

Positive Control 2

Cat. No. 10-901 - Human Spleen Tissue Slide

NCBI Official Name

Cathelicidin antimicrobial peptide

NCBI Organism

Homo sapiens

Background Reference 01

Zaiou M and Gallo RL. Cathelicidins, essential gene-encoded mammalian antibiotics. J. Mol. Med. 2002; 80:549-61.

Background Reference 02

Agerberth B, Gunne H, Odeberg J, et al. FALL-39, a Putative Human Peptide Antibiotic, is Cysteine-Free and Expressed in Bone Marrow and Testis. Proc. Natl. Acad. Sci. USA 1995; 92:195-9.