Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

TDP43 Antibody

Product Specifications

Background

TDP43 Antibody: TDP43 was initially identified as a novel cellular protein that bound to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3'splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U) . TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.

NCBI Gene ID

23435

Swiss Prot

Q13148

Accession Number

ABO32290

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

TDP43 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1201 - HeLa Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Chicken: (100%)

Buffer

TDP43 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TDP43 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=4283

Fragment

IgG

Specificity

At least two isoforms are known to exist for this protein; this TDP43 antibody will recognize both isoforms.

Symbol

TARDBP

Positive Control 2

Cat. No. 17-001 - HeLa Cell Slide

NCBI Official Name

TAR DNA binding protein

NCBI Organism

Homo sapiens

Background Reference 01

Ou SH, Wu F, Garcia-Martinez LF, et al. Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. J. Virol.1995; 69:3584-96.

Background Reference 02

Buratti E, Dork T, Zuccato E, et al. Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. EMBO J.2001; 20:1774-84.

Background Reference 03

Neumann M, Sampathu DM, Kwong LK, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science2006; 314:42-3.

Other Product Names

TDP43 Antibody: ALS10, TDP-43, TDP43, TAR DNA-binding protein 43

Tested Applications

ELISA, WB, ICC, IF

Protein ID

130750552

Physical Properties

Liquid

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

G Protein-Coupled Receptor 27 (GPR27) Antibody
abx328071-01 50 µg

G Protein-Coupled Receptor 27 (GPR27) Antibody

Ask
View Details
G Protein-Coupled Receptor 27 (GPR27) Antibody
abx328071-02 100 µg

G Protein-Coupled Receptor 27 (GPR27) Antibody

Ask
View Details
Rabbit Polyclonal PGRMC1 Antibody [CoraFluor 1]
NBP2-36525CL1 0.1 mL

Rabbit Polyclonal PGRMC1 Antibody [CoraFluor 1]

Ask
View Details
Anti-equine IFN-γ mAb (MT13), biotin
3117-6-1000 1 mg

Anti-equine IFN-γ mAb (MT13), biotin

Ask
View Details
Mouse IL-17 RB Phycoerythrin MAb (Clone 752101)
FAB10402P-025 25 Tests

Mouse IL-17 RB Phycoerythrin MAb (Clone 752101)

Ask
View Details