FABP7 Antibody

Product Specifications

Background

FABP7 Antibody: FABP7 was initially isolated from a human fetal brain cDNA library and whose mRNA was expressed in adult brain and muscle tissues at low levels. The protein encoded by this gene is a member of the fatty acid binding protein (FABPs) family, a group of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism. FABP7 is a downstream gene of the Pax6 transcription factor and has been suggested to be essential for the maintenance of neuroepithelial cells during early cortical development. More recently, FABP7 was found to be frequently expressed in melanomas. Down-regulation of FABP7 through RNAi expression could reduce in vitro cell proliferation and Matrigel invasion, suggesting that FABP7 may be a potential target for the development of diagnostic and therapeutic tools.

NCBI Gene ID

2173

Swiss Prot

O15540

Accession Number

EAW48166

Host

Rabbit

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Homeostasis

Purification

FABP7 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1311 - Human Breast Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Chicken: (94%), Rat: (94%), Mouse: (88%)

Buffer

FABP7 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

FABP7 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

FABP7

Positive Control 2

Cat. No. 10-001 - Human Breast Tissue Slide

NCBI Official Name

Fatty acid binding protein 7, brain

NCBI Organism

Homo sapiens

Background Reference 01

Shimizu F, Watanabe TK, Shinomiya H, et al. Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP) . Biochim. Biophys. Acta1997; 1354:24-8.

Background Reference 02

Chmurzynska A. The multigene family of fatty acid-binding proteins (FABPs) : function, structure and polymorphism. J. Appl. Genet.2006; 47:39-48.

Background Reference 03

Arai Y, Funatsu N, Numayama-Tsuruta K, et al. Role of FABP7, a downstream gene of pax6, in the maintenance of neuroepithelial cells during early embryonic development of the rat cortex. J. Neurosci.2005; 25:9752-61.

Background Reference 04

Goto Y, Matsuzaki Y, Kurihara S, et al. A new melanoma antigen fatty acid-binding protein 7, involved in proliferation and invasion, is a potential target for immunotherapy and molecular target therapy. Cancer Res.2006; 66:4443-9.