IFN-beta Antibody

Product Specifications

Background

IFN-beta Antibody: Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by "Natural IFN-producing cells" (IPCs) as part of the host immune response and can also inhibit the development of tumors. IFN-beta binding by its receptor results in the activation of the tyrosine kinases Jak1 and Tyk2 and phosphorylation of members of the STAT family of transcription factors, leading to the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

NCBI Gene ID

3456

Swiss Prot

P01574

Accession Number

AAC41702

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

4243

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Independent Antibody Validation in Cell lines (Figure 2) shows similar IFN-beta expression profile in human and mouse cell lines detected by two independent anti-IFN-beta antibodies that recognize different epitopes, 4243 against central domain and 64-239 against human recombinant protein. IFN-beta proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines4243 64-239 Recombinant Protein Test (Figure 3) : Anti-IFN-beta antibodies (4243) detected human IFN-beta recombinant protein. Recombinant Protein Test4243

Field of Research

Immunology, Inflammasomes

Purification

IFN-beta Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1288 - A20 Cell Lysate

Concentration

1 mg/mL

Buffer

IFN-beta Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

IFN-beta antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human IFN-beta has one (187aa, 22kD) . Mouse IFN-beta has one isoform (182aa, 22kD) and Rat IFN-beta also has one isoform (184aa, 22kD) . 4243 can detect human isoform, and possibly detect mouse and rat.

Symbol

IFNB1

Positive Control 2

Cat. No. 1304 - Human Liver Tissue Lysate

Positive Control 3

Cat. No. 10-201 - Human Liver Tissue Slide

NCBI Official Name

Interferon, beta 1, fibroblast

NCBI Organism

Homo sapiens

Background Reference 01

Gresser. J. Leuk. Biol.1997; 61:567-74.

Background Reference 02

Colonna. Eur. J. Immunol.2007; 37:306-9.

Background Reference 03

Kock et al. Ann. Neurol.2007; epub.

Other Product Names

IFN-beta Antibody: IFB, IFF, IFNB, IFB, Interferon beta, Fibroblast interferon, IFN-beta

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

184623

Physical Properties

Liquid

Available Sizes

Curated Selection

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