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Op18 Antibody

Product Specifications

Background

Op18 Antibody: Op18 belongs to the stathmin family of genes and encodes a ubiquitous cytosolic phosphoprotein that may function as an intracellular relay integrating several signaling pathways such as those involved in cell proliferation and differentiation. Op18 has also been shown to be involved in the regulation of the microtubule filament system by destabilizing microtubules, thereby preventing assembly and promoting the disassembly of microtubules. More recently, op18 has been implicated as a potential target of the ASK1-p38 MAP kinase cascade, suggesting that the ASK1-p38 cascade may regulate microtubule dynamics through op18. Op18 is highly expressed in a wide variety of human malignancies, including leukemia, prostate cancer, ovarian carcinoma, and breast carcinoma, suggesting that op18 may be an ideal target for anti-cancer therapeutics.

NCBI Gene ID

3925

Swiss Prot

P16949

Accession Number

AAH82228

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

4235

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Independent Antibody Validation in Cell lines (Figure 2) shows similar op18 expression profile in human, mouse and rat cell lines detected by two independent anti-op18 antibodies that recognize different epitopes, 4235 against C-terminus domain and 4237 against N-terminus domain. op18 proteins are detected in the most tested cell lines at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines4235 4237

Field of Research

Homeostasis

Purification

Op18 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1287 - EL4 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Pig: (100%), Bovine: (100%), Chicken: (95%)

Buffer

Op18 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Op18 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=4235

Fragment

IgG

Isoform

Human op18 has 2 isoforms, including isoform 1 (149aa, 17kD) and isoform 2 (174aa, 20kD) . Mouse op18 has one isoform (149aa, 17kD) and rat op18 also has one isoform (149aa, 17kD) . 4235 can detect only human isoform 1and it can also detect mouse and rat op18.

Symbol

STMN1

Positive Control 2

Cat. No. 1303 - Human Brain Tissue Lysate

Positive Control 3

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

STMN1

NCBI Organism

Homo sapiens

Background Reference 01

Curmi et al. Cell Structure and Function 1999; 24:345-57.

Background Reference 02

Belmont et al. Cell 1996; 84:623-31.

Background Reference 03

Mizumura et al. J. Cell Physiol. 2006; 206:363-70.

Background Reference 04

Mistry et al. Mount Sinai J. Med. 2002; 69:299-304.

Other Product Names

Op18 Antibody: Lag, SMN, OP18, PP17, PP19, PR22, LAP18, C1orf215, Stathmin, Leukemia-associated phosphoprotein p18, Op18

Tested Applications

ELISA, WB, IHC-P

Protein ID

51895905

Physical Properties

Liquid

Available Sizes

Curated Selection

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