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STIM2 Antibody

Product Specifications

Background

STIM2 Antibody: In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER) -like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist. This STIM2 antibody is predicted to have no cross-reactivity to STIM1.

NCBI Gene ID

57620

Swiss Prot

Q9P246

Accession Number

NP_065911

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

STIM2 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1288 - A20 Cell Lysate

Concentration

1 mg/mL

Buffer

STIM2 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

STIM2 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=4123

Fragment

IgG

Symbol

STIM2

Positive Control 2

Cat. No. 1306 - Human Spleen Tissue Lysate

Positive Control 3

Cat. No. 10-901 - Human Spleen Tissue Slide

NCBI Official Name

Stromal interaction molecule 2

NCBI Organism

Homo sapiens

Background Reference 01

2+

Background Reference 02

Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature2006; 441:179-85.

Background Reference 03

2+2+

Background Reference 04

Ca2+

Other Product Names

STIM2 Antibody: KIAA1482, Stromal interaction molecule 2

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

41349446

Physical Properties

Liquid

Available Sizes

Curated Selection

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