What is the catalog number for ORAI1 Antibody?

The catalog number for ORAI1 Antibody is 4041.

What sizes are available for ORAI1 Antibody?

ORAI1 Antibody is available in the following size(s): 0.02 mg, 0.1 mg.

How many pack sizes does ORAI1 Antibody come in?

ORAI1 Antibody is available in 2 different pack sizes.

Is ORAI1 Antibody in stock?

ORAI1 Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

ORAI1 Antibody

Product Specifications

Background

ORAI1 Antibody: Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor.

NCBI Gene ID

84876

Swiss Prot

Q96D31

Accession Number

Q96D31

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology

Purification

ORAI1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1316 - Human Ovary Tissue Lysate

Concentration

1 mg/mL

Buffer

ORAI1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

ORAI1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Specificity

This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

Symbol

ORAI1

Positive Control 2

Cat. No. 1306 - Human Spleen Tissue Lysate

Positive Control 3

Cat. No. 11-201 - Human Ovary Tissue Slide

Positive Control 4

Cat. No. 10-901 - Human Spleen Tissue Slide

NCBI Official Name

ORAI calcium release-activated calcium modulator 1

NCBI Organism

Homo sapiens

Background Reference 01

Lewis RS. Calcium signaling mechanisms in T lymphocytes. Annu. Rev. Immunol. 2001; 19:497-521.

Background Reference 02

Feske S, Gwack Y, Prakriya M, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 2006; 441:179-85.

Background Reference 03

Soboloff J, Spassova MA, Dziadek MA, et al. Calcium signals mediated by STIM and Orai proteins - a new paradigm in inter-organelle communication. Biochim. Biophys. Acta. 2006; 1763:1161-8.