TRBP1 Antibody

Product Specifications

Background

TRBP1 Antibody: The human trans-activation response (TAR) RNA binding protein 1 (TRBP1) was initially identified as a protein that binds to the HIV-1 TAR RNA and activates the long terminal repeat (LTR) expression in the absence and presence of the viral trans-activator Tat. This binding is enhanced by the presence of co-factors such as elongation factor 1α (EF-1α ), polypyrimidine tract-binding protein (PTB), and the chaperonin-like protein stimulator of TAR RNA-binding proteins (SRB) . TRBP1 may act to disengage RNA polymerase II from TAR during transcriptional elongation if the RNA polymerase stalls at the TAR during transcriptional elongation.

NCBI Gene ID

6894

Swiss Prot

Q13395

Accession Number

NP_005637

Host

Rabbit

Reactivity

Human, Mouse

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Infectious Disease

Purification

TRBP1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1212 - 3T3 Cell Lysate

Concentration

1 mg/mL

Buffer

TRBP1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TRBP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Symbol

TARBP1

NCBI Official Name

TAR (HIV-1) RNA binding protein 1

NCBI Organism

Homo sapiens

Background Reference 01

Gatignol A, Buckler-White A, Berkhout B, et al. Characterization of a human TAR REN-binding protein that activates the HIV-1 LTR. Science 1991; 251:1597-1600.

Background Reference 02

Wu-Baer F, Lane WS, and Gaynor RB. Identification of a group of cellular cofactors that stimulate the binding of RNA polymerase II and TRP-185 to human immunodeficiency virus 1 TAR RNA. J. Biol. Chem.1996; 271:4201-8.