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APH1 Antibody

Product Specifications

Background

APH1 Antibody: APH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gamma-secretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma- and epsilon-sites and can lead to the accumulation of the Amyloid beta peptide (Abeta) cleavage product that is associated with Alzheimer's disease. APH1 exists in at least three distinct isoforms with APH1a as the principal isoform present in the gamma-secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed.

NCBI Gene ID

51107

Swiss Prot

Q96BI3

Accession Number

AAH08732

Host

Rabbit

Reactivity

Human, Mouse, Rat

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

APH1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1283 - RAW 264.7 Cell Lysate

Concentration

1 mg/mL

Buffer

APH1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

APH1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=4003

Fragment

IgG

Symbol

APH1A

Positive Control 2

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Anterior pharynx defective 1 homolog A (C. elegans)

NCBI Organism

Homo sapiens

Background Reference 01

Goutte C, Tsunozaki M, Hale VA, et al. APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc. Natl. Acad. Sci. USA2002; 99:775-9.

Background Reference 02

Periz G and Fortini ME. Functional reconstitution of γ secretase through coordinated expression of presenilin, nicastrin, aph-1, and pen-2. J. Neurosci. Res. 2004; 77:309-22.

Background Reference 03

Selkoe DJ. The cell biology of β amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 1998; 8:447-53.

Background Reference 04

Ma G, Li T, Price DL, et al. APH-1a is the principal mammalian aph-1 isoform present in g-secretase complexes during embryonic development. Neuro. Dis. 2005; 25:192-8.

Other Product Names

APH1 Antibody: APH-1, APH-1A, CGI-78, 6530402N02Rik, PSF, UNQ579/PRO1141, Gamma-secretase subunit APH-1A, Aph-1alpha, APH-1a

Tested Applications

ELISA, WB, IHC-P

Protein ID

14250557

Physical Properties

Liquid

Available Sizes

Curated Selection

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