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TIM-1 Antibody

Product Specifications

Background

TIM-1 Antibody: The human form of TIM-1 was initially discovered as a membrane glycoprotein through which the hepatitis A virus can gain entry into a cell. It was also identified as kidney injury molecule 1 (Kim-1), a predicted adhesion molecule that is upregulated on the surfaces of kidney epithelia. It is also expressed on T helper 2 (Th2) cells of the immune system, and following the binding of its natural ligand TIM-4, stimulates T cell expansion and cytokine production in response to viral challenge. It has been suggested that hyperactivation of TIM-1 leads to an increased level of Th2 responsiveness and asthma susceptibility, and antibodies to TIM-1 may therefore be a novel approach to treating asthma.

NCBI Gene ID

26762

Swiss Prot

Q96D42

Accession Number

NP_036338

Host

Rabbit

Reactivity

Human

Immunogen

3811

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Independent Antibody Validation in Cell lines (Figure 2) shows similar TIM-1 expression profile in human cell lines detected by two independent anti-TIM-1 antibodies that recognize different epitopes, 3809 against N-terminus domain and 3811 against the central domain. TIM-1 proteins are detected in all the tested cell lines except MCF-7 at different expression levels by the two independent antibodies. Independent Antibody Validation in Cell lines3809 3811 siRNA knockdown validation (Figure 3) : Anti-TIM-1 antibody (3811) specificity was further verified by TIM-1 specific siRNA knockdown. TIM-1 signal in HeLa cells transfected with TIM-1 siRNAs was much weaker in comparison with that in HeLa cells transfected with control siRNAs. siRNA knockdown validation3811

Field of Research

Immunology, Neuroscience, Signal Transduction, Growth Factors

Purification

TIM-1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1202 - A431 Cell Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Mouse: (50%), Rat: (43.7%)

Buffer

TIM-1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TIM-1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=3811

Fragment

IgG

Isoform

Human TIM-1 has 5 isoforms, including isoform a precursor (364aa, 39kD), isoform a (364aa, 39kD), isoform b precursor (401aa, 44kD), isoform b (359aa, 39kD), and isoform c (359aa, 39kD) . This antibody detects human isoform b precursor. Mouse TIM-1 has 3 isoforms, including isoform a precursor (305aa, 33kD), isoform b precursor (282aa, 31kD) and isoform b (282aa, 31kD) . Rat TIM-1 has only one isoform identified so far (307aa, 34kD) .

Symbol

HAVCR1

Positive Control 2

Cat. No. 1203 - A549 Cell Lysate

Positive Control 3

Cat. No. 1224 - Daudi Cell Lysate

Positive Control 4

Cat. No. 1210 - 293 Cell Lysate

NCBI Official Name

Hepatitis A virus cellular receptor 1

NCBI Organism

Homo sapiens

Background Reference 01

Feigelstock et al. J. Virol. 1998; 72:6621-8

Background Reference 02

Ichimura et al. J. Biol. Chem. 1998; 273:4135-42

Background Reference 03

Meyers et al. Mol. Med. 2005; 11:362-9

Background Reference 04

Mayers et al. Nat. Immunol. 2005;6:455-64.

Other Product Names

TIM-1 Antibody: TIM, KIM1, TIM1, HAVCR, KIM-1, TIM-1, TIMD1, TIMD-1, HAVCR-1, Hepatitis A virus cellular receptor 1, Kidney injury molecule 1, HAVcr-1

Tested Applications

ELISA, WB

Protein ID

153085427

Physical Properties

Liquid

Available Sizes

Curated Selection

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