IL-23 Antibody

Product Specifications

Background

IL-23 Antibody: Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-α from activated T cells, and can stimulate macrophages to produce TNF-α and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.

NCBI Gene ID

51561

Swiss Prot

Q9NPF7

Accession Number

AAH66268

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

3795

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Recombinant Protein Test (Figure 2) : Anti-IL-23 antibodies (3795) detected human IL-23 recombinant protein at different concentrations. Recombinant Protein Test3795 Induced Expression Validation (Figure 6) : IL-23 expression detected by anit-AIF antibodies was up-regulated by tape stripping. Induced Expression Validation

Field of Research

Immunology, Chemokines & Cytokines, Neuroscience

Purification

IL-23 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1414 - Mouse Pancreas Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Horse: (94%), Pig: (82%), Rat: (76%), Guinea pig: (76%)

Buffer

IL-23 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

IL-23 antibody can be stored at 4˚ C up to one year. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human IL-23 has one isoform (189aa, 20.7kD) . Mouse IL-23 has one isoform (196aa, 22.1kD) and Rat IL-23 also has one isoform (196aa, 22kD) . 3795 can detect human and mouse, and possibly detect rat.

Symbol

IL23A

NCBI Official Name

Interleukin 23, alpha subunit p19

NCBI Organism

Homo sapiens

Background Reference 01

Hunter. Nat. Rev. Immunol. 2005; 5:521-31.

Background Reference 02

Oppmann et al. Immunity 2000; 13:715-25.

Background Reference 03

Sheibanie et al. FASEB J. 2004; 18:1318-20.

Background Reference 04

Pirhonen et al. J. Immunol. 2002; 169:5673-8.

Citation 01

27551155

Other Product Names

IL-23 Antibody: P19, SGRF, IL-23, IL-23A, IL23P19, UNQ2498/PRO5798, Interleukin-23 subunit alpha, Interleukin-23 subunit p19, IL-23 subunit alpha

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

42542809

Physical Properties

Liquid

Available Sizes

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