TWEAK Antibody

Product Specifications

Background

TWEAK Antibody: TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.

NCBI Gene ID

8742

Swiss Prot

O43508

Accession Number

NP_003800

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

3791

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Validation

Recombinant Protein Test (Figure 2) : Anti-TWEAK antibodies (3791) detected human TWEAK recombinant protein at different concentrations. Recombinant Protein Test3791

Field of Research

Apoptosis, Cancer

Purification

TWEAK Antibody is Protein A-purified.

Positive Control

Cat. No. 1303 - Human Brain Tissue Lysate

Concentration

1 mg/mL

Buffer

TWEAK Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TWEAK antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human TWEAK has 2 isoforms, including isoform 1 (249aa, 27kD) and isoform 2 (330aa, 36kD) . Mouse TWEAK has one isoform (249aa, 27kD) and Rat TWEAK also has one isoform (249aa, 27kD) .

Symbol

TNFSF12

Positive Control 2

Cat. No. 1201 - HeLa Cell Lysate

Positive Control 3

Cat. No. 10-301 - Human Brain Tissue Slide

NCBI Official Name

Tumor necrosis factor (ligand) superfamily, member 12

NCBI Organism

Homo sapiens

Background Reference 01

Wiley and Winkles. Cyto. And Growth Factor Rev. 2003; 14:241-9.

Background Reference 02

Chicheportiche et al. J. Biol. Chem. 1997; 272:32401-10.

Background Reference 03

Lynch et al. J. Biol. Chem. 1999; 274:8455-9.

Background Reference 04

Chicheportiche et al. Arthr. Res. 2002; 4:126-33. 5.

Other Product Names

TWEAK Antibody: APO3L, DR3LG, TWEAK, APO3L, UNQ181/PRO207, Tumor necrosis factor ligand superfamily member 12, APO3 ligand

Tested Applications

ELISA, WB, IHC-P, IF

Protein ID

4507597

Physical Properties

Liquid

Available Sizes

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