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TL1A Antibody

Product Specifications

Background

TL1A Antibody: Members in the TNF and its receptor superfamilies regulate immune responses and induce apoptosis. DR3 (also termed Wsl-1, Apo-3, TRAMP, and LARD) is preferentially expressed by T lymphocytes and upregulated during T cell activation. The ligand for DR3 was recently identified and designated TL1A. TL1A also binds decoy receptor DcR3/TR6, which is expressed in several lung and colon carcinomas and in some normal tissues. TL1A induces apoptosis and NF-κ B activation in DR3 expressing cells, which is antagonized by DcR3. TL1A is upregulated by proinflammatory cytokines TNF and IL-1. TL1A is a longer variant of TL1 (also called VEGI) .

NCBI Gene ID

9966

Swiss Prot

O95150

Accession Number

AAM77366

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

TL1A antibody was raised against recombinant human TL1A.

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis

Purification

TL1A Antibody is Protein A purified.

Positive Control

Cat. No. 1309 - Human Placenta Tissue Lysate

Concentration

1 mg/mL

Buffer

TL1A Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

TL1A antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=3789

Fragment

IgG

Specificity

TL1A will not cross-react with TL1.

Symbol

TNFSF15

NCBI Official Name

Tumor necrosis factor (ligand) superfamily, member 15

NCBI Organism

Homo sapiens

Background Reference 01

Chinnayan AM, O'Rourke K, Yu GL, et al. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95. Science 1996; 274:990-2.

Background Reference 02

Kitson J, Raven T, Jiang YP, et al. A death-domain-containing receptor that mediates apoptosis. Nature 1996; 384:372-5.

Background Reference 03

Screaton GR, Xu XN, Olsen AL, et al. LARD: a new lymphoid-specific death domain containing receptor regulated by pre-mRNA splicing. Proc. Natl. Acad. Sci. USA 1997; 94:4615-9.

Background Reference 04

Bodmer JL, Burns K, Schneider P. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas (Apo-1/CD95) . Immunity 1997; 6:79-88.

Other Product Names

TL1A Antibody: TL1, TL1A, VEGI, VEGI192A, TL1, Tumor necrosis factor ligand superfamily member 15, TNF ligand-related molecule 1

Tested Applications

ELISA, WB

Protein ID

21745392

Physical Properties

Liquid

Available Sizes

Curated Selection

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